A foundational understanding of disease biology and pathophysiology serves as the roadmap for successful drug discovery and development efforts. It requires the researcher to identify the key pathways and targets fundamental to disease initiation, progression and manifestation. Unraveling these disease mechanisms and interplay of molecular processes can pave the way for the design of targeted therapies that address the root causes of disease.
Developing this understanding is not always simple: diseases are complex and multifaceted, with intricate interactions between genetic, environmental, and lifestyle factors. Heterogeneity within diseases further complicates the picture, requiring a nuanced approach for personalized treatments. Additionally, diseases can exhibit diverse manifestations across various body systems, demanding a holistic understanding of their systemic impact.
Build comprehensive understanding of the disease state
- Discover insights quickly by diving into the disease biology. Investigate how disease is formed across therapeutic areas by looking at the causative and cellular mechanisms, the specific genes or proteins involved in its development and how they are regulated or expressed in specific cell types.
- Explore pathways to connect what happens upstream or downstream of a gene, enzyme or target. Use it to deeply understand the relationship between disease and the gene, protein or target at the tissue, genetic or cellular level, especially for diseases where the disease biology is not yet well understood.
Knowledge graph based hypothesis generation
- Uncover hidden biochemical pathways or molecular processes that mediate the effects of a gene or protein on disease using the multi-hop module.
Collaborate to build shared understanding
- Collaborate among multidisciplinary teams, including biologists, pharmacologists, and computational biologists, to enhance the understanding of disease pathophysiology.
- Easily share novel findings, data, and resources to help fill knowledge gaps and create a holistic view of the disease mechanisms.
Build comprehensive understanding of the disease state
- Discover insights quickly by diving into the disease biology. Investigate how disease is formed across therapeutic areas by looking at the causative and cellular mechanisms, the specific genes or proteins involved in its development and how they are regulated or expressed in specific cell types.
- Explore pathways to connect what happens upstream or downstream of a gene, enzyme or target. Use it to deeply understand the relationship between disease and the gene, protein or target at the tissue, genetic or cellular level, especially for diseases where the disease biology is not yet well understood.
Improve Target Prioritization
Identify and prioritize drug targets that are more likely to be involved in the pathogenesis of the disease.
Increase Likelihood of Therapeutic Success
Rational drug design based on the understanding of underlying mechanisms, pathways and molecular interactions involved in the disease enables more targeted therapies.
Therapeutic Areas Resources
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